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Current estimates place the market size at approximately $XX billion, with projections suggesting an 8-10% CAGR over the next five years

Van Dieren et al., 2007), and more recent studies have shown that low ITPA enzyme activity was not always correlated with side effects from thiopurine therapy (Shipkova et al., 2011

For the latter, termed complex core diversification or late-stage functionalization, the synthetic power of this concept is readily apparent as the positional (as well as stereoisomeric) analogs of complex starting materials are accessed with high efficiency when compared to lengthy de novo approaches 30,31,32,33,34,35,36