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Mechanism of Action: Anoikis and Apoptosis Once Adipotide binds to prohibitin on the endothelial surface, it is internalized into the cell

This is also true for the newborn screening of inborn errors of vitamin B 12 metabolism found in the cblD, cblF, and cblJ (Huemer et al., Figure 2 Methylmalonic acid MMA increases upon inactivation of AdoCbl-dependent MCM in the mitochondrion

In other patients, the dose may not yet be optimized, or side effects may prevent adequate titration