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PLoS One 7 (8), e43483

48,53 Once synthesized in the cytosol, these precursor proteins, bearing distinctive amino-terminal cleavable targeting motifs, are recognized and translocated by the translocase of the outer/inner membrane (TOM/TIM) complex, such as TOM20, TOM22, TOM40, and TIM23

Abbreviations KOA: Knee osteoarthritis LPS: Lipopolysaccharide FLS: Fibroblast-like synoviocytes AMPK: AMP-activated protein kinase CPT1: Carnitine palmitoyltransferase 1 Cyc: Cytochrome c ACLT: Anterior cruciate ligament transection NSAIDs: Non-steroidal anti-inflammatory drugs CoA: Coenzyme A SOD: Superoxide dismutase MDA: Malonaldehyde ATP: Adenosine-triphosphate ROS: Reactive oxygen species CCK-8: Cell counting kit-8 DMEM: Dulbeccos modified Eagles medium IL-1: Interleukin-1 siRNA: Small interfering RNA References Sharma L

475,476 In the phase 3 GeparQuinto trial, bevacizumab was added to patients treated with anthracycline and taxane, which significantly improved the pCR rate in BRCA1 /2 mutation carriers