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however, the conformational changes of the transporters during the transport cycle (Figure 2) can largely alter the structure of the binding sites complicating the rationale for the observed selectivity for known inhibitors

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Nguyen HL, Linh HQ, Krupa P et al (2022) Amyloid dodecamer disrupts the neuronal membrane more strongly than the mature fibril: understanding the role of oligomers in neurotoxicity