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This unexpectedly promotes fibroblast activation and proliferation, thereby accelerating the fibrotic process ( 6.3.5 Targeting extracellular matrix remodeling Targeted inducers of matrix metalloproteinases (MMPs) exert complex effects on macrophage function in thyroid eye disease by regulating extracellular matrix remodeling: on the one hand, they may break the physical confinement of macrophages by moderately degrading excessively deposited fibrotic matrix, thereby promoting a shift from a pro-fibrotic phenotype towards an anti-inflammatory reparative state

This activated the phenylpropanoid biosynthesis pathway, leading to the upregulated expression of CAD, POD and other related genes

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