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NNMT inhibitor caused weight loss and reduced adipose tissue mass in DIO mice Since in vitro studies showed 5-amino-1MQ to have high cell permeability, enzyme selectivity, and cell culture efficacy, a sub-chronic (11-day) proof-of-concept in vivo study was conducted to test the effect of NNMT inhibition on obesity in HFD fed mice

Once reconstituted, store at 2-8C and use within 30 days

Cartilage degeneration was scored using the Yoshimi scale, which ranges from 0, defined as normal cartilage, to 5, defined as complete loss of cartilage