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This is mainly due to rapid oxidation in plasma rather than by increased tissue extraction or volume distribution

Future research should focus on expanding cohort diversity and size, integrating multi-omics approaches, and systematically assessing the impact of antiepileptic therapies to elucidate the complex metabolic pathways underpinning epilepsy

171 Although research into brain stimulation is in its early stages, case reports of successful treatment using stimulation to the brain cortex or deeper brain structures indicate the potential for this method to be helpful in patients with severe tinnitus that has not responded to other therapies

PMID 25913846