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Medicinal Chemistry is a scientific discipline involved with designing, synthesizing and developing pharmaceuticals suitable for therapeutic use Highly interdisciplinary science combining genetics, molecular biology, biochemistry, organic chemistry, pharmacology, toxicology Outline Background Drug Metabolism Pharmacogenetics Examples CYP2D6 Codeine DDI Scenario (fluoxetine) ALDH2 Ethanol DDI Scenario (acetaminophen) Basic Vocabulary Lipophilicity vs Hydrophilicity Lipophile: Fat-lover Hydrophile: Water-lover Xenobiotic: a foreign chemical substance More Basic Vocabulary Metabolism: chemical reactions that occur in living organisms Enzyme: a biomolecule that catalyzes a chemical reaction Inducer Enzyme Xenobiotic Metabolite Inhibitor Todays Focus We will focus on the enzymatic conversion of lipophilic xenobiotics to more water soluble metabolites