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The in vivo antioxidant protection aligns with the polyphenolic profile of the extract: quercetin, apigenin, myricetin and their derivatives act as potent radical scavengers (azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH)) and metal-reducing agents (Ferric Reducing Antioxidant Power (FRAP)), validating in vitro antioxidant assays (Reference Arce-Ortiz, Jimnez-Martnez and Gutirrez-Rebolledo9)

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Vitamin D also plays a modulatory role, increasing the expression of critical endogenous antioxidant enzymes, such as SOD1 (108)

More nonsynonymous than synonymous mutations were detected between paired antrum and corpus populations suggesting that selection pressures were acting independently within and between these regions (Suppl