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While previous studies emphasize that the forebrain, cerebellum, and inferior olive (IO) are crucial for learning new motor policies and forming memory, the dynamic process by which these brain regions detect error signals, explore new strategies, and update new circuits to downstream regions remain less understood

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Data availability The datasets generated and analysed, supporting the conclusions of this article, are available to download from Abbreviations CNTF: Ciliary neurotrophic factor GBA: Gut-brain axis BDNF: Brain-derived neurotrophic factor CNS: Central nervous system PFA: Paraformaldehyde NORT: Novel object recognition test MWM: Morris water maze ELISA: Enzyme-linked immunosorbent assay ROS: Reactive oxygen species TBARS: Thiobarbituric acid reactive substances MDA: Malonaldehyde GSH: Glutathione TCA: Trichloroacetic acid IHC: Immunohistochemistry ECL: Chemiluminescence BBB: Blood-brain barrier GFAP: Glial Fibrillary Acidic Protein IBA-1: Ionised Calcium-binding Adaptor Molecule 1 References Ahlawat S, Asha, Sharma KK