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DE indicates the dry eye group

For all three-dimensional individualized stereotactic coordinates of the bilateral NAc and the stereotactic horizontal and vertical angles of bilateral lead placement in AC-PC system, no significant differences were found between the absolutely abstinent patients and the other patients (Supplementary Table 8), and the results were the same as the normalized stereotactic coordinates of the bilateral NAc in MNI space (Supplementary Tables 10 and 11)

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The metabolites were identified by OSI/SMMS software (Dalian ChemData Solution Information Technology Co., Ltd., China), MSDIAL (version 5.1.221218), and other online databases, including Human Metabolome Database ( Lipidmaps ( and LipidBlast ( Statistical analysis Statistical analysis of clinical data and differential metabolites was performed using the SPSS 22.0, GraphPad Prism 8.0, and MetaboAnalyst 5.0