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During host cell infection, CoVs trigger an imbalance involving increased ROS production and reduced antioxidant host responses, thereby leading to increased redox stress, reduced antiviral host responses, and increased virus-induced inflammation and apoptosis, ultimately causing cell and tissue damage and end-organ disease 3

This effect has been attributed to their ability to increase airway surface liquid osmolarity and to exert mild antiseptic and anti-inflammatory effects through elevated pH and calcium and/or magnesium ion interactions with the airway epithelium and mucus structure

1-10 Magnesium sulfate injection should be used during pregnancy only if clearly needed

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