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The quantitative data mentioned above on a depletion of the total specific content of ATP in cultured astrocytes by application of inhibitor of ATP regenerating pathways have been confirmed by ATP sensor studies showing a corresponding decline in the cytosolic ATP content of astrocytes in different model systems (Table 4)

This combination therapy has exhibited enhanced cell-killing effects both in vivo and ex vivo , suggesting a potential synergistic approach in cancer treatment ( In terms of immunotherapy, TH1579 does not appear to compromise the antitumor responses induced by anti-CTLA-4 antibody treatment in melanoma

All animals were required to undergo institutional quarantine for 7 days prior to use

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