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This happens because doxycycline can bind to calcium in teeth, leading to discoloration

Within the first 40 h, TAM and its metabolites were reduced by half after a single dose of TAM with TAM (9.9 h), 4-OH-TAM (15.8 h) and NMD-TAM (19.9 h) being cleared faster than END (33.2 h)

Speaker: Ms Xuwei Zhao (Tongji University) 129 Transformative Planning for Sustainable Futures: Bridging Global Goals and Local Actions through Adaptive Frameworks Abstract Planning has been the key transformative action during these times of highly increasing global crises such as climate change, loss of biodiversity, and socio-economic inequality