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3.1 IL-6/IL-6R with different inhibitors One meta-analysis of IL-6 concentration levels found that patients with complicated COVID-19 had 2.9-fold higher levels than those with uncomplicated disease (Ulhaq and Soraya, 2020), indicating that the IL-6 level was a perfect predictor of poor prognosis in COVID-19 (Table 2

"Mechanical injury potentiates proteoglycan catabolism induced by interleukin6 with soluble interleukin6 receptor and tumor necrosis factor in immature bovine and adult human articular cartilage." Arthritis & Rheumatism: Official Journal of the American College of Rheumatology 60.10 (2009): 2985-2996

ROS can oxidatively modify regulatory subunits of the IB kinase (IKK) complex, promoting IB phosphorylation and subsequent degradation via the ubiquitin-proteasome pathway, thereby releasing active NF-B dimers (e.g., p50-p65) for nuclear translocation (S-Pessoa et al., 2023