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First, in the cytosol, VPA is activated and links with reduced acetyl coenzyme A (CoA-SH) to form valproyl-CoA (by the ATP-dependent medium-chain acyl-CoA synthetase, located on the outer side of the mitochondrial membrane)

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Primary end points for Cohort 1 included hematologic, renal, liver, and other chemistry, mineral, and electrolyte abnormalities and the incidence of new SARS-CoV-2 infections in the supplement group compared with that in the placebo group

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