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10.1016/j.mayocp.2018.09.013 42 SpalingerM

Unlike traditional static metabolomics, which provides only a snapshot of metabolite concentrations, this approach allows for real-time quantification of carbon flux through specific metabolic pathways, offering dynamic insights into altered hepatic metabolism

Cycle length typically runs 8 to 12 weeks, followed by a 4 to 6 week rest period, with cycles repeated 2 to 3 times per year

Zhu et al 51 first prepared folic acid-conjugated liposomes loaded with docetaxel, followed immediately by an inhalable dry powder using spray drying technique, which showed higher cellular uptake, cytotoxicity, tumor targeting properties and drug exposure accompanied by low drug exposure in other organs