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Storage: Room temperature, away from light

Although the presence of adult ovarian cortical GSCs requires further confirmation [261], indirect evidence from animal models suggests that mouse primordial germ cells (PGCs) predominantly rely on glycolysis in their quiescent state and transition to OXPHOS upon activation or differentiation

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Cyst(e)ine and GPX4 inhibition as therapeutic targets To exploit our findings in vivo, we first tested simultaneous inhibition of cysteine uptake and transsulfuration in vitro using IKE, an erastin analog with acceptable pharmacokinetic properties 40,41 , and PPG 33 (Fig