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It is important to emphasize that activation of the JAKSTAT3 pathway and the upregulation of GFAP should not be interpreted as substate-specific markers of astrocyte reactivity 139

doi:10.1016/j.neuropharm.2012.09.005 [doi] Bries AE, Webb JL, Vogel B, Carrillo C, Keating AF, Pritchard SK, Roslan G, Miller JW, Schalinske KL., Letrozole-Induced Polycystic Ovary Syndrome Attenuates Cystathionine-

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HSA human serum albumin Figure 2 Schematic representation of antibody construct domains being differently charged at about neutral pH and similarly positively charged at lower pH