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investigated the combined effects of Lily polysaccharide (LLP) and Astragalus polysaccharide (APS) in a specific ratio on depressive-like behaviors and their modulation of the adenylyl cyclase/cyclic adenosine monophosphate/protein kinase A (AC/cAMP/PKA) signaling pathway in mice subjected to chronic stress ( The studies suggest that depression induces neuronal atrophy and loss in limbic regions of the brain, such as the hippocampus, prefrontal lobe, and amygdala, along with a decrease in BDNF expression

10.1177/0022034518817351 38 DingL.HanS.WangK.ZhengS.ZhengW.PengX.et al (2020)

Mittler et al., 2022) that can cause damage such as lipid degradation, protein degradation, nucleic acid damage, and induce programmed cell death (PCD) (Das and Roychoudhury, 2014)

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