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In a mouse model of colitis induced by dextran sulfate sodium salt, oral administration of baicalin solution (100 mg/kg) was shown to restore colon length and spleen index to near normal levels, alleviate ulcer severity, decrease the expression of CD14 and IL-6 in the colonic mucosa, reduce the binding of Toll-like receptor 4 (TLR4), and inhibit the activation of the myeloid differentiation primary response protein 88 (MyD88)/NF-B p65 pathway, and the positive control drug mesalazine showed similar protective effects, can effectively improve the main indicators of the disease, thus effectively exerting an anti-colitis effect (Fu et al., 2021)
& Larsen, G
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