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6 The relative role of ethanol, its metabolite acetaldehyde, congeners (other alcohols and organic compounds produced during fermentation or introduced during beverage production), co-exposures such as tobacco smoke, other substances, and dancing is also unclear

Therefore, while aware that the pharmacological modulation of the NRF2/ARE pathway could undeniably offer new therapeutic opportunities for diseases related to OS, we should at the same time consider that most of the currently known activators of NRF2 are not particularly specific, leading to an increased risk of off target toxic effects

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Diabetes 1 , 119120 (2000)