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Collectively, these factors result in exceedingly low bioavailability, defined as the fraction of the ingested compound that reaches systemic circulation in an active form, thereby limiting the therapeutic and nutritional efficacy of such agents

Riboflavin also plays a role in thyroxine metabolism, and its deficiency may contribute to mental illness, because riboflavin activates vitamin B6, leading to lower thyroxine levels, reduced hypothalamic serotonin synthesis, and decreased levels of S-adenosylmethionine (SAMe), because of disrupting the folate-methylation pathways involved in SAMe synthesis, all of which are associated with antidepressant effects, consequently, low levels of these compounds may cause depression ( Figure 4 ) (48, 49)

Biomaterials 219, 119357

Multi-functional application of Moringa oleifera Lam