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The disease is progressive, and the symptoms usually get worse overtime

Besides the morphine-antagonist naloxone, the central dopamine antagonist haloperidol has also been tested, presenting this peptide's close interaction with the dopamine system (11, 15-17, 19)

Paradoxically, this more reducing redox environment correlated with increases in mitochondrial oxidation and cell death, suggesting that elevated GSH levels result in reductive stress and cytotoxicity (117)

When setting target INRs, pharmacists and healthcare professionals will usually use a local protocol, which is most often based on current guidelines from the British Committee for Standards in Haematology (BCSH) [5]