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10.1016/j.yjmcc.2013.11.009 J

Since were using an enzyme that dissolves collagen, you want to ensure its injected only in the exact right places, and that requires a physician or advanced practitioner who understands the anatomy and who has been trained in this specific procedure

This aberrant immune-vascular crosstalk not only generates an endothelial barrier that hinders T-cell infiltration into the tumor but also impairs T-cell effector functions and even leads to T cell apoptosis within the TME 2,4,8,9,10

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