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Description

Within the mitochondria, electron leakage from complexes I and III of the electron transport chain generates superoxide, which is subsequently converted to hydrogen peroxide by superoxide dismutase (SOD2)

In patients with active IBD, pro-inflammatory cytokines such as TNF-, IL-1, IL-6, IL-12, and IL-23 are significantly elevated, while anti-inflammatory cytokines such as IL-10 and IL-4 are expressed at insufficient levels [59, 60]