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A side-by-side illustration of cannula versus needle use in the infraorbital region: The cannula technique is shown creating a wide, even filler distribution with minimal trauma, making it ideal for patients with delicate skin or high vascular risk

We showed that RSPO2-deficient mice have reduced active -catenin signalling and a decreased mineral deposition rate and osteoblast number, similar to the phenotype observed with the knockout of LRP5/6