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This interaction is part of a coevolutionary relationship between hosts and microbes, with particular relevance to tryptophan-derived AhR ligands [50, 51]

453 Another study utilizing machine learning identified that low total cholesterol, high urea nitrogen and bilirubin, and prolonged thrombin time were strongly associated with early mortality, particularly in pediatric HLH patients

Successful PROTAC design demands the concurrent optimization of multiple attributes, ternary complex stability, cellular permeability, pharmacokinetics, and tissue selectivity, a challenge for which AI is uniquely suited given its capacity to process high-dimensional, heterogeneous datasets [280, 281]