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There are a number of reasons for the spine to experience degenerative changes, one of which is natural age-related spinal degeneration, and when the spine starts to deteriorate, its ability to maintain its natural curves and alignment can be affected

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Abnormal changes in posttranslational modifications, especially phosphorylation at serine 129 (ser129) (p--syn), are critical for the transition of -syn from a physiological to pathological function [9]

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