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In a randomized placebo-controlled trial that included 101 participants with fibromyalgia, those who received 3 mg or 5 mg of melatonin nightly in addition to antidepressant therapy with fluoxetine had improvement on Fibromyalgia Impact Questionnaire scores after eight weeks

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These typically resolve within 24-48 hours

Why Feeling Better Is Not the Same as Being Healed Pain relief can happen before healing is complete