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In a model induced by repeated Brucella antigen injections, hippocampal atrophy was accompanied by reduced DG neurogenesis, increased granule-cell apoptosis, and decreased BDNF expression (Moriya et al., 2011)

353,354 In one trial, the increase in slow-wave sleep was correlated with increased subjective next-morning vigor

While the precise mechanism linking SYK to MCT1 control requires further elucidation, we propose a model whereby SYK, via PI3K/AKT/mTOR signaling, sustains the expression of HIF-1 and c-Myc, which are known transcriptional regulators of the SLC16A1 gene (encoding MCT1) [49, 50]

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