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The lactulose/mannitol or lactulose/rhamnose ratio increases in patients with multiple sclerosis, rheumatoid arthritis, type 1 diabetes, or celiac disease ( Table 1 Autoimmune diseases related to LGS and dysbiosis

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307 The JAK/STAT3 signaling pathway, one of the most important modes of STAT signaling, regulates cell function through cytokine-receptor interactions, activation of the JAK protein kinase, and phosphorylation of the STAT protein

Vesell Professor of Pharmacology at Penn State College of Medicine, and they continue to shape health and medicine today