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Currently, no correlation between STG levels in blood or urine and exposure has been demonstrated for humans and more research is needed to fully understand the human in vivo metabolism of STG

Practically, this decoupling allows for two separate production streams, enabling independent optimization of folding and post-translational modifications, though it necessitates balancing antigen size with manufacturing complexity and production economics (Park et al., 2023

Restoration of p53 activity through exogenous TP53 gene expression has become both a treatment concept for p53-deficient cancers and an important milestone in gene replacement therapy ( Figure 3 )