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In particular, miRNAs are well-known regulators of adhesion, invasion, metastatic process [6] and recently, emerging evidence supports their role in the regulation of cancer metabolism

Researchers should still document regulatory framing accurately in study design

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Topical agents like retinoids, vitamin E can be used but there is little evidence supporting their benefits in this phase ( Chronic ulceration Removal of the necrotic tissue and employing advanced therapies like skin substitutes, growth factors, and hyperbaric oxygen may be beneficial for non-healing ulcers ( Hyperpigmentation/telangiectasia For vascular lesions or telangiectasia (these are small visible blood vessels that appears on skin