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doi: 10.1016/s0014-5793(03)00641-0 58 NieHYiW

Morrison et al

Available online at: (Accessed September 26, 2025)

Moreover, signaling pathways commonly associated with stemness, notably the Notch, Hedgehog, and PI3K/AKT/mTOR pathways, intersect with metabolic regulators, forming feedback loops that tightly control energy production, biosynthesis, and cell fate decisions