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In addition, a systematic umbrella review, which examined the major areas of research regarding the hypothesis that serotonin is deficient during depression, found no evidence that brain deficiency or low activity of the neurotransmitter is at the root of the psychiatric disorder [10]

doi: 10.1089/scd.2019.0220

Insulin-like growth factor long arginine 3 (IGF-1 LR3), is a widely used synthetic analog of IGF-1 with an arginine replacing glutamic acid at position 3 (arginine 3, R3), and an additional 13 amino acids at its N-terminus (long, L)