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Notably, edaravonean RTA clinically approved for treating acute ischemic stroke and amyotrophic lateral sclerosis 135 has been shown to protect against ferroptosis under various pathological conditions

However, there is some independent published clinical evidence that suggests potential benefits from repeated dose treatment with high levels of injected vitamin D3, adenosylcobalamin and methylcobalamin (both forms of Vitamin B12)

Experimental Neurology, 143 , 269281

Apoptosis is regulated by the balance between pro-apoptotic proteins (Bax, Bak) and anti-apoptotic proteins (Bcl-2), with p53 promoting pro-apoptotic gene expression [31]