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Neurological issues brought on by pernicious anemia include memory and concentration issues, tingling and numbness in the hands and feet, and balance issues Pernicious anemia can lead to nerve damage Pernicious anemia can lead to heart failure Pernicious anemia can lead to an increased risk of infection and cancer Birth abnormalities and pregnancy difficulties including miscarriage can result from pernicious anemia

Our group previously reported on the modification of exocyclic amines of nucleobases with activated furan (keto-enal) 32,33

These toxins accumulate in mitochondria and induce oxidative damage [49]

A possible advantage of a small bending modulus of the cytoplasmic membrane might be that it reduces the energy cost for the process of squeezing the RBC through small capillaries