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About this article Cite this article Zhu, S., Guo, Q., Zheng, Y

A larger change in sleep duration deviation across timepoints was associated with higher TSPO levels at T2 in all ROIs except for the frontal cortex (95% CI [0.00, 0.23]), indicating that individuals whose sleep duration deviated more from optimal sleep over the 5-year period (i.e., sleep duration that became short or longer than the recommended eight hours) had higher TSPO levels at T2 (adjusted for sex, age, retirement status, and TSPO gene (for gray matter) or gray matter volume of distribution (VT) (for all other ROIs)

Furthermore, the authors found that acetate supplementation decreased the activation of autoreactive T cells while butyrate supplementation increased the number and function of regulatory T cells, thereby preventing autoimmune development of T1D [202]