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Consequently, optimisation of nose-to-brain delivery is frequently achieved through a combination of targeted deposition in upper nasal regions and permeability-enhancing excipients as well as nanocarrier systems that protect the active pharmaceutical ingredient (API) from enzymatic degradation and facilitate mucosal transport (Chung et al., 2023, Dhuria et al., 2010, Illum, 2003)

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Circulation 105(1):112117 Morikawa S et al (2002) Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors

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