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Studies have shown that tamoxifen resistance is associated with IGFBP-1 accumulation and that the overexpression of IGFBP-1 promotes tamoxifen resistance in breast cancer cells by activating the ERK pathway, which can be reversed by knocking down IGFBP-1 (134)

Studies highlight their role in IGF-1 activity, repair processes, and systemic resilience in preclinical settings

The peptide's unusual gastric stabilitysurviving extreme pH conditionsdistinguishes it from most peptides, but in solution it remains susceptible to oxidation, hydrolysis, and bacterial contamination

Figure 3 GSTP Enters the Nucleus and Interacts with HMGB1 in Response to LPS Stimulation The immunoblotting analysis and confocal microscopy observation showed that nuclear GSTP protein level can be detected within 5 min after LPS treatment and peaked at 1 h (Figures 4AC)