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Shoveller [email protected] This article was submitted to Animal Nutrition and Metabolism, a section of the journal Frontiers in Veterinary Science Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Statistical significance was determined using a two-tailed Students t -test

Clinically, melatonin has been reported to reduce the risk of hemorrhagic transformation after tissue plasminogen activator (t-PA) therapy in ischemic stroke (150, 151), suggesting a potential role in improving thrombolytic safety through modulation of BBB permeability

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