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D.AndriankajaA.AllenS.KakarK.et al (2008)

Defective T-cell receptor signaling leads to aberrant Th17 cell differentiation, altering gut microbiota composition and subsequently driving systemic autoimmune disease [38]

In a post-hoc single-cell RNA sequencing analysis, data from patients with RMC before and after nivolumab plus ipilimumab treatment indicated that immune checkpoint therapy (ICT) triggered an interferon- response that induced a myeloid mimicry program in tumor cells, regulated by the CEBPB / p300 axis and linked to proliferation and hyperprogression