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TB-500, the 43-amino acid form of Thymosin Beta-4 originally isolated from bovine thymus, serves as the dominant G-actin sequestering protein in mammalian cells, orchestrating cytoskeletal dynamics that underlie cellular migration, tissue remodeling, and cardiovascular protection while activating integrin-linked kinase pathways essential for cell survival and repair

Despite the development of numerous drugs targeting specific pathological features of AD, such as amyloid-beta (A) deposition and neurofibrillary tangles, very few have been approved in the past 20 years, underscoring the limitations of single-target therapeutic approaches

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Thus, the use of this approach allowed to identify an original target, the protein kinase DYRK1B, suggesting that an inhibitor of this protein could present a possible senolytic activity 40