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On the other hand, under the regulation of various cells and their secreted cytokines, key transcriptional regulation pathways such as TLR2/4-NF-B, p38/MAPK, IL-6/STAT3, and others participate in the immune-inflammatory interactions underlying diabetic vascular complications, ultimately leading to vascular damage and barrier disruption, triggering diabetes-related macrovascular and microvascular complications (Odegaard et al., 2016

In the brain, most effects of alcohol on histone methylation are gene-specific, resulting in changes in gene expression that are consistent with alcohols effects on DNA methylation and contribute to the pathophysiology of AUD (8292)

Cell 76 , 981997 (2019)