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The mechanistic case is strong and the symptom relief is often real : dehydration and electrolyte loss explain much of how a hangover feels, IV fluids correct both directly and immediately, and antiemetic and anti-inflammatory add-ons target nausea and headache that genuinely respond to those agents

Another study showed that DFO could suppress excessive collagenase-mediated type II collagen cleavage and protease, production of cytokine, and COL10A1 expression while upregulating adenosine monophosphate-activated protein kinase and Krebs cycle genes in human osteoarthritic cartilage [125]

doi: 10.1523/jneurosci.19-02-00562.1999 203

Or would it make no difference