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Nutr Metab (Lond) 22 , 56 (2025)

Periwinkle contains vincamine, a compound that improves microcirculation and blood flow in the periocular capillaries reducing the pooled blood that makes dark circles visible through thin under-eye skin

Combination chemotherapy and immunotherapy was investigated in a phase II trial of eribulin with or without pembrolizumab in patients who had received 02 prior lines of chemotherapy and at least two lines of hormonal therapy, which did not show an ORR, PFS or OS benefit.[94]