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Moreover, Wang et al (138) found that AS-IV pretreatment concentration-dependently suppresses -SMA, FN and collagen IV expression in MCs induced by HG and the prohibitive effect of AS-IV on the activation and proliferation of MCs induced by HG is still related to autophagy activation mediated by SIRT1-NF-B signaling transduction

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Putrescine transport is greatly increased in human fibroblasts initiated to proliferate

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