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Energy balance is the dominant driver of weight change and metabolic health

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For instance, tumors with constitutive PI3K activation are resistant to dietary restriction 41 , and colorectal cancers without KRAS mutation show less significant synergized efficacy of the combination of fasting and vitamin C 61

the latter would typically also comprise an inert and physiologically-acceptable carrier or diluent, such as water, physiological saline, bacteriostatic saline, a petrolatum based cream, a pharmaceutically acceptable gel, a short chain alcohol, or a short chain glycol a disclosed composition may be combined with a suitable agent to provide a cosmetic preparation, as would be appreciated by one skilled in the art