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Given sex imbalance across groups, sex-stratified analyses were conducted

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Meanwhile, the increased MDA level directly confirmed enhanced lipid peroxidation and oxidative stress injury ( 20-COOH-LTB 4 , a natural antagonist and terminal metabolite of leukotriene B4 (LTB4), was upregulated following MA exposure, indicating activation of the upstream LTB4-driven pro-inflammatory pathway ( 4 showed dose-dependent accumulation